Although the Class I cabinet protects the operator and the environment from exposure to biohazards, it does not protect samples from airborne contaminants present in room air. This creates a risk of cross-contamination, potentially affecting experimental consistency. Consequently, Class I cabinets have limited applications.
Θάλαμοι Νηματικής Ροής
Οι θάλαμοι νηματικής ροής δημιουργούν έναν ελεγχόμενο, αποστειρωμένο χώρο εργασίας μέσω συνεχούς ροής φιλτραρισμένου αέρα, προστατεύοντας τα δείγματα από επιμολύνσεις. Είναι κατάλληλοι για εφαρμογές όπως η καλλιέργεια φυτικών ιστών, η προετοιμασία θρεπτικών υλικών και η συναρμολόγηση ηλεκτρονικών εξαρτημάτων.
Περιγραφή
Biological Safety Cabinets (BSC)
Reliable Protection for Safe Biological Sample Handling
Biological Safety Cabinets (BSCs) are designed for handling pathogenic biological samples and applications requiring a sterile work zone.
Inflow and downflow air provide operator protection, while ULPA/HEPA-filtered downflow creates an ISO Class 3 work zone to protect samples from cross-contamination. Exhaust air is also ULPA/HEPA-filtered before release to protect the environment.
Esco BSCs offer a wide range of configurations, including work trays, side panel options, and accessories, with ergonomic and energy–saving features. To ensure optimum performance, they are tested and classified according to EN 12469:2000 and NSF 49.
EN 12469:2000, Biotechnology — Performance Criteria for Microbiological Safety Cabinets, is a European standard published by CEN (European Committee for Standardization). It classifies biological safety cabinets into Class I, Class II, and Class III.
The NSF International Biological Safety Cabinetry Program was initiated in the 1970s at the request of regulatory organizations, including the Centers for Disease Control (CDC), National Institutes of Health (NIH), and National Cancer Institute (NCI). NSF 49 further classifies Class II biological safety cabinets according to their air circulation systems: Type A1, Type A2, Type B1, and Type B2.
Class I Biological Safety Cabinet
The Class I cabinet features the most basic design among biological safety cabinets. Inward airflow contains aerosols generated during microbiological procedures and directs them through a filtration system that captures airborne particles and contaminants. The decontaminated air is then exhausted from the cabinet. The filtration system typically consists of a pre-filter and a HEPA (High Efficiency Particulate Air) filter.
Must-have features to consider:
✅ Compact design suitable for small laboratory spaces
✅ DC-ECM blower for 70% energy savings compared to AC motors
✅ Basic rocker switches for easy operation
✅ Compliance with EN 12469
✅ Wide range of accessories and options
✅ VHP port integration
✅ UV lamp for decontamination
✅ Isocide™ powder coating that inhibits microbial growth
Class II Biological Safety Cabinet
The Class II Biosafety Cabinet is mainly used for handling pathogenic biological samples or for applications that require a sterile work zone. A biological safety cabinet is designed to have: an inflow for protecting the operator, an ULPA/HEPA-filtered downflow which creates an ISO Class 3 work surface that prevents cross contamination for protecting the sample, and an ULPA/HEPA-filtered exhaust for protecting the environment.
Class II biological safety cabinets are divided into three types—A2, B1, and B2—based on their airflow and exhaust systems.
✅ Type A2: Recirculates 70% of the air as downflow and exhausts the remaining 30% through a HEPA filter. Positive-pressure contaminated plenums are surrounded by negative pressure to help prevent contaminated air from escaping in the event of leakage.
✅ Type B1: Exhausts 70% of the air and recirculates 30% as downflow. A dedicated exhaust system prevents recirculation in the rear work area. Toxic chemicals may be used only when their recirculation does not interfere with the work.
✅ Type B2: Exhausts 100% of the air without recirculation, making it suitable for microbiological procedures involving toxic chemicals. Total exhaust provides an additional safety measure in the event of downflow or exhaust HEPA filter failure. These cabinets require larger laboratory spaces and dedicated ductwork.
Must-have features to consider:
✅ Certified to NSF 49 and EN 12469
✅ Side panel construction options
✅ Choice of multipiece or single-piece worktrays
✅ DC-ECM blower for 70% energy savings compared to AC motors
✅ Broad range of sizes to suit different laboratory spaces
✅ Stable, self-compensating airflow despite building voltage fluctuations and filter loading
✅ UV lamp for decontamination
✅ Airflow sensor to alert users when airflow is insufficient
✅ Alarm for unsafe sash conditions
✅ Ergonomic raised armrest helps prevent grille blockage and promotes a comfortable working posture
✅ Isocide™ powder coating that inhibits microbial growth
Class II Models Overview
Specifications:
■ Available in three sash opening models: 8”, 10”, and 12”
■ Dimmable LED lighting system
■ Centurion touchscreen controller
■ Standby height activates standby mode while maintaining an ISO Class 3 work zone with the fan running at half speed
■ USB port to relay operational parameters to Building Management System (BMS)
■ Remote Modbus
■ Default cable port
■ Optional 21 CFR Compliance
■ Stainless steel interior
■ Single-piece work tray
■ DC ECM blower for up to 70% energy savings
■ Low power consumption
■ Available width sizes: 3 ft, 4 ft, 5 ft, and 6 ft
Specifications:
■ Dimmable LED lighting system
■ Centurion touchscreen controller
■ Standby height activates standby mode while maintaining an ISO Class 3 work zone with the fan running at half speed
■ USB port to relay operational parameters to Building Management System (BMS)
■ Remote Modbus
■ Default cable port
■ Optional 21 CFR Compliance
■ E-Series: Multi-piece work tray, glass sidewalls
■ DC ECM blower for up to 70% energy savings
■ Low power consumption
■ Available width sizes: 2 ft, 3 ft, 4 ft, 5 ft, and 6 ft
Specifications:
■ Dimmable LED lighting system
■ Centurion touchscreen controller
■ USB port to relay operational parameters to Building Management System (BMS)
■ Remote Modbus
■ Default cable port
■ Optional 21 CFR Compliance
■ S-Series: Single-piece work tray, stainless steel sidewalls
■ Available width sizes: 4 ft and 6 ft
Specifications:
■ E.G. Steel back wall
■ Multi-piece work tray
■ Glass sidewall
■ Two DC ECM motors for a redundant system that provides protection in case of power failure
■ Sentinel™ Gold microprocessor controller
■ Low-noise operation
■ Available width sizes: 4 ft and 6 ft
Class III Biological Safety Cabinet
Class III biological safety cabinets provide the highest level of containment compared with Class I and Class II cabinets. They feature a gas-tight, welded metal construction and are operated through glove ports at the front. Negative pressure is maintained inside the cabinet relative to the surrounding environment, providing an additional safety measure in the event of compromised containment.
All exhaust air passes through a HEPA filter and is incinerated. Materials are introduced through a side-mounted pass-through unit. Exhaust air is typically returned to the laboratory, but can also be discharged outdoors through dedicated ductwork, allowing the cabinet to be used for applications involving toxic chemicals alongside microbiological processes.
Must-have features to consider:
✅ Dual exhaust ULPA filters provide better protection than single-stage designs.
✅ User-friendly control system.
✅ Single-piece, leak-tested Neoprene™ gauntlets for maximum protection.
✅ Integrated pass-through unit with interlocking doors enables material transfer while preventing environmental contamination.
✅ Angled cabinet front ensures a comfortable working posture.
✅ Rear-mounted Magnehelic gauge for easy monitoring of the work zone.
✅ Audible and visual alarms notify users of unsafe conditions.
✅ Isocide™ powder coating inhibits microbial growth.
Class III Models Overview
Specifications:
■ Dual exhaust ULPA filter
■ Negative–pressure work zone
■ Magnehelic™ gauge for pressure monitoring
■ Sentinel™ Silver microprocessor controller
■ Single-piece, leak-tested Neoprene™ gauntlets
■ Ergonomically angled front
■ Available sizes: 4 ft, 5 ft, and 6 ft
Specifications:
■ Double–filtered exhaust air via ULPA filters
■ Single-piece, leak-tested glove assemblies for maximum protection
■ Fully welded stainless steel construction: 316L for internal chambers and 304 for the external housing
■ Suitable for handling Biosafety Levels 1–4
■ Available sizes: 4 ft, 5 ft, and 6 ft
Specifications:
■ ISO Class 3 work zone
■ Superior operator protection for cytotoxic drug handling
■ Fast purging time
■ Motorized height stand
■ Suitable for cytotoxic drug handling
■ Available sizes: 4 ft and 6 ft
Specifications:
■ Automated airflow and pressure control
■ LED lighting for superior illumination
■ Oval-shaped glove ports to maximize arm movement
■ Hydraulic support frame legs for operator comfort
■ Suitable for hazardous and non-hazardous drug handling
■ Available sizes: 4 ft, 5 ft, and 6 ft
Class III biological safety cabinets provide the highest level of containment for work involving hazardous biological agents, combining gas-tight construction, glove-operated handling, and high-efficiency exhaust filtration. With different configurations, sizes, and features available, they support demanding laboratory applications across Biosafety Levels 1–4, helping protect operators, samples, and the surrounding environment.
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